AISLING S. DUGAN
Assistant Professor of Biology
Human Biology, Microbiology
Dissecting the interactions that occur between BK virus and its human host cell.
B.A., Smith College, Biological Science, 2000
Ph.D., Brown University, Biology and Medicine, 2007
Postdoctoral Fellowship, Tufts University, 2009
Jordan JA, Manley K, Dugan AS, O’Hara BA, Atwood WJ. Journal of Virology. 2010. 84 (4): 1722-30.
Li Z, Dugan AS, Bloomfield G, Skelton J, Ivens A, Losick V, Isberg RR. DupA: a key regulator of the amoebal MAP kinase response to Legionella pneumophila. Cell Host & Microbe. 2009. 6 (3): 253-267.
Gasparovic ML, Maginnis MS, O’Hara BA, Dugan AS, Atwood WJ. Modulation of PML protein expression regulates JCV infection. Virology. 2009. 390 (2): 279-288.
Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O’Hara BA, Atwood WJ. Human alpha-defensins inhibit BK Virus by aggregating virions and blocking binding to host cells. Journal of Biological Chemistry. 2008. 283 (45): 31125-31132.
Dugan AS, Gasparovic ML, Atwood WJ. Direct correlation between sialic acid binding and infection of cells by two human polyomaviruses (JCV and BKV). Journal of Virology. 2008. 82 (5): 2560-2564.
Dugan AS, Gasparovic ML, Tsomaia N, Mierke DF, O’Hara BA, Manley K, Atwood WJ. Identification of amino acid residues in BK virus VP1 that are critical for viability and growth. Journal of Virology. 2007. 81 (21): 11798-11808.
Dugan AS, Eash S, Atwood WJ. Update on Bk Virus entry and intracellular trafficking. Transplant Infectious Disease, 2006. 8 920: 62-67
Sample of Invited Lectures
Alpha-defensins, HNP-1 and HD5, inhibit primate polyomavirus infection of host cells. American Society for Virology, Ithaca, NY. 2008
The role of charged amino acids in VP1 in BK Virus lifecycle. 4th International Conference on Polyomavirus and Human Disease, Barcelona, Spain. Sept. 2007.
Identification of amino acid residues in BK Virus VP1 critical for viability and growth. Pathobiology Graduate Program Annual Retreat, Bristol, RI. Aug. 2007.
BK Virus interaction with sialic acid receptors on host cells. American Society for Virology, Madison, WI. July 2006.
An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK Virus. 3rd International Conference on Polyomavirus and Human Disease, Providence, RI. Sept. 2005.
BK Virus interaction with sialic acid on receptors of host cells. Keystone Symposium: Cell Biology of Virus Entry, Replication and Pathogenesis, Santa Fe, NM (Poster Presentation). Feb. 2006